Electron Microscopy Data Bank

EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

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sample_name:"~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (~{E})-but-2-enethioate"

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EMD-17843

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Asymmetric unit of the yeast fatty acid synthase with ACP at the enoyl reductase domain (FASam sample)

Release date: Nov. 22, 2023
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8ps2
Q-score: 0.575

Singh K, Bunzel G, Graf B, Yip KM, Neumann-Schaal M, Stark H, Chari A

Cell (2023) 186 pp. 5054-5067.e16 [ DOI: doi:10.1016/j.cell.2023.10.009 Pubmed: 37949058 ]

Sample:

Yeast fatty acid synthase (Complex from Saccharomyces cerevisiae)
~{s}-[2-[3-[[(2~{r})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (~{e})-but-2-enethioate (426 Da, Ligand)
Malonyl-coenzyme a (853 Da, Ligand)
Fatty acid synthase subunit beta (228 kDa, Protein from Saccharomyces cerevisiae)
Fatty acid synthase subunit alpha (207 kDa, Protein from Saccharomyces cerevisiae)
Flavin mononucleotide (456 Da, Ligand)

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